This Tech Note explains how the Array SPRi platform is a high-throughput biophysical tool designed to address the throughput needs of lead generation and primary screening groups.
This App Note describes how a high throughput, array-based SPR imaging (SPRi) assay for screening FcγR kinetics and steady state affinities against IgGs with the integrated Wasatch Microfluidics Continuous Flow Microspotter (CFM) and the IBIS MX96 imaging platform.
This white paper describes the importance of determining epitope diversity early in the discovery process. Epitope binning via array-based SPR can be a powerful tool in this effort, as it enables the binning of 96 mAbs in a single automated run, with less than 200uL of each mAb consumed. The paper also presents the custom software Wasatch has developed for rapid processing of these large data sets.
In this white paper, a new method is presented for the antibody epitope discovery at the amino acid level. Antigens contain many undetermined epitopes which all can be a target for antibodies.
This white paper describes the determination of the kinetic rate and equilibrium affinity constants of Fc – VH interactions as performed in the labs of Crescendo Biologics, Cambridge, UK.
In this application note, a new method is presented for discovery and mapping of the immunogenic epitopes of auto-antigens. Antigens containing undetermined antigenic epitopes were subjected to tryptic digestion and then separated using strong cation exchange liquid chromatography.