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TECHNOLOGY NOTE: High Throughput Biophysical Characterization of mAb Panels

This Tech Note explains how the Array SPRi platform is a high-throughput biophysical tool designed to address the throughput needs of lead generation and primary screening groups.

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APPLICATION NOTE: High Throughput Epitope Binning

This App Note describes how high throughput epitope binning is possible with our Continuous Flow Microspotter (CFM).

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APPLICATION NOTE: Multiplex SPRi Screening of Fc-Gamma Receptor Affinities

This App Note describes how a high throughput, array-based SPR imaging (SPRi) assay for screening FcγR kinetics and steady state affinities against IgGs with the integrated Wasatch Microfluidics Continuous Flow Microspotter (CFM) and the IBIS MX96 imaging platform.

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APPLICATION NOTE: First-Pass Kinetics(TM) Screening of Captured Antibodies

This App Note explains our unique way of Screening of Captured Antibodies.

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BROCHURE: MX96 SPR Imager + CFM Array Printer

This brochure describes how SPR has captured the power of the array. The combination of the IBIS MX96 detector and the CFM printer unleashes the full power of SPR array analysis.

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WHITE PAPER: Array SPR Applications - Epitope Binning

This white paper describes the importance of determining epitope diversity early in the discovery process. Epitope binning via array-based SPR can be a powerful tool in this effort, as it enables the binning of 96 mAbs in a single automated run, with less than 200uL of each mAb consumed. The paper also presents the custom software Wasatch has developed for rapid processing of these large data sets.

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IBIS WHITE PAPER: Epitope mapping at the amino acid level

In this white paper, a new method is presented for the antibody epitope discovery at the amino acid level. Antigens contain many undetermined epitopes which all can be a target for antibodies.

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IBIS WHITE PAPER: Affinity of Fc – VH interactions

This white paper describes the determination of the kinetic rate and equilibrium affinity constants of Fc – VH interactions as performed in the labs of Crescendo Biologics, Cambridge, UK.

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IBIS WHITE PAPER: Binning of antibodies‐Tandem

This white paper is one in a series that addresses various protocols for binning of antibodies either using sandwich, premix or tandem protocols.

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IBIS APPLICATION NOTE: Rheumatoid arthritis biomarker discovery

In this application note, a new method is presented for discovery and mapping of the immunogenic epitopes of auto-antigens. Antigens containing undetermined antigenic epitopes were subjected to tryptic digestion and then separated using strong cation exchange liquid chromatography.

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DATA SHEET: CFM Flow Printing

This data sheet describes the unsurpassed deposition uniformity using CFM technology.

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DATA SHEET: Crude Lysate

This data sheet describes printing antibodies from crude lysates using CFM technology.

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